Search on: PLECKSTRIN HOMOLOGY DOMAINS 
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Descriptor English:   Pleckstrin Homology Domains 
Descriptor Spanish:   Dominios Homólogos a Pleckstrina 
Descriptor Portuguese:   Domínios de Homologia à Plecstrina 
Synonyms English:   PH Domain
PH Domains
Pleckstrin Homology Domain
Domain, PH
Domain, Pleckstrin Homology
Domains, PH
Domains, Pleckstrin Homology
Homology Domain, Pleckstrin
Homology Domains, Pleckstrin  
Tree Number:   G02.111.570.820.709.275.750.469
Definition English:   Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS. 
History Note English:   2017 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   56742 
Unique Identifier:   D000070539 

Occurrence in VHL: 		 

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